ABSTRACT
Acute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists.
TABLE OF CONTENTS
part A|76 pages
Introduction to the Acute Phase Response
part B|175 pages
The Major Acute Phase Proteins: Their Structure and Possible Function in Acute Phase Response
chapter Chapter 6|10 pages
The α1-Acid Glycoprotein: Structure and Possible Functions in the Acute Phase Response
chapter Chapter 7|31 pages
Proteinase Inhibitors: An Overview of their Structure and Possible Function in the Acute Phase
chapter Chapter 12|16 pages
RAT α 2 -Macroglobulin and Related α-Macroglobulins in the Acute Phase Response
chapter Chapter 13|13 pages
Rat Thiostatin: Structure and Possible Function in the Acute Phase Response
part C|19 pages
Systems in which to Study Regulation of Acute Phase Proteins
part D|89 pages
The Cytokines and Hormones Implicated in Acute Phase Protein Regulation
chapter Chapter 17|11 pages
Interleukin-11: Molecular Biology. Biological Activities, and Possible Signaling Pathways
part E|164 pages
Regulation of Acute Phase Protein Gene Expression
chapter Chapter 21|31 pages
Regulation of C-Reactive Protein, Haptoglobin, and Hemopexin Gene Expression
chapter Chapter 23|15 pages
Regulation of α1-Acid glycoprotein genes and Relationship to Other Type 1 Acute Phase Plasma Proteins
chapter Chapter 26|28 pages
Regulation of the Rat α2-Macroglobulin Gene by Interleukin-6 and Leukemia Inhibitory Factor
part F|18 pages
Signal Transduction of Cytokines in Hepatocytes
chapter Chapter 29|16 pages
Signal Transduction Mechanisms Regulating Cytokine-Mediated Induction of Acute Phase Proteins
part G|55 pages
Post-Transcriptional Processes
part H|61 pages
Clinical Applications