ABSTRACT
This book explores the factors which are critical in the selection of an appropriate animal species for toxicology studies and the subsequent extrapolation of the data to humans. It provides some future directions for risk assessment activities at the Environmental Protection Agency.
TABLE OF CONTENTS
part 1|36 pages
Current industrial practices and regulatory status of animal selection and extrapolation
part 2|51 pages
Use of physiological and toxicological data from man and animals as aids in animal selection and extrapolation
part 3|51 pages
Metabolic and pharmacokinetic considerations in species selection
part 4|65 pages
Animal selection considerations in carcinogenic and reproductive toxicity
part 5|59 pages
Pharmacogenetic and human monitoring considerations in animal selection
