Abstract: Consumers in apparel industry expect end products to be safe in use, compliant with product safety regulations, reduce risk to workers who produce the product and the environment wherein the product is produced, and help to protect the company and brands from liability. Non-compliance to the safety norms leads to custom's seizure, product recall, penalties, lawsuit, and brand liability. The chapter first begins with the discussion of various safety issues and related performance requirements of apparel products. The chapter then discusses sources of restricted substances and evaluation of restricted substances in apparel thereof. Legal regulations of harmful substances and product compliance to protect the environment are also highlighted.