ABSTRACT
This authoritative, single-source reference provides comprehensive examinations of the complement system-offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases.
Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease
Introduction and Historical Notes, Michael M. Frank
Molecular Architecture
Overview of the Complement System, John E. Volanakis
Clq and Mannose-Binding Lectin, Kenneth B. M. Reid
Complement Enzymes, John E. Volanakis and Gérard J. Arlaud
The Chemistry and Biology of C3, C4, and C5, John D. Lambris, Arvind Sahu, and Rick A. Wetsel
Proteins of the Membrane Attack Complex, Mnason E. Plumb and James M. Sodetz
Regulatory Proteins of Complement, M. Kathryn Liszewski and John P. Atkinson
Complement Receptors, Joseph M. Ahearn and Ariella M. Rosengard
Phylogeny of the Complement System, Masaru Nonaka
Regulation of Complement Protein Gene Expression, Harvey R. Colten and Gérard Garnier
Biology
Characterization of Complement Anaphylatoxins and Their Biological Responses, Julia A. Ember, Mark A. Jagels, and Tony E. Hugli
Complement-Mediated Phagocytosis, Melvin Berger
Cellular Responses to the Membrane Attack Complex, Carolyn Mold
Regulation by Complement of Acquired Immunity, Michael C. Carroll and Douglas T. Fearon
Endothelial Cell Responses to Complement Activation, Soheyla Saadi and Jeffrey L. Platt
The Complement System in Reproduction, Teresa J. Oglesby
Bacteria and Complement, Franz Petry and Michael Loos
Complement and Viruses, Neil R. Cooper
Complement and Disease
Complement Deficiencies and Infection, Peter Densen
Processing and Clearance of Immune Complexes by Complement and the Role of Complement in Immune Complex Diseases, Kevin A. Davies and Mark J. Walport
C1 Inhibitor Gene and Hereditary Angioedema, Alvin E. Davis III
Paroxysmal Nocturnal Hemoglobinuria and Complement, Wendell F. Rosse Complement in Central Nervous System Disorders, Moon L. Shin, Horea Rus, and Florin Niculescu
Development of Clinically Useful Agents to Control Complement-Mediated Tissue Damage, Eric Wagner and Michael M. Frank
Autoimmune Hemolytic Anemia, Alan D. Schreiber
Complement an
Molecular Architecture
Overview of the Complement System, John E. Volanakis
Clq and Mannose-Binding Lectin, Kenneth B. M. Reid
Complement Enzymes, John E. Volanakis and Gérard J. Arlaud
The Chemistry and Biology of C3, C4, and C5, John D. Lambris, Arvind Sahu, and Rick A. Wetsel
Proteins of the Membrane Attack Complex, Mnason E. Plumb and James M. Sodetz
Regulatory Proteins of Complement, M. Kathryn Liszewski and John P. Atkinson
Complement Receptors, Joseph M. Ahearn and Ariella M. Rosengard
Phylogeny of the Complement System, Masaru Nonaka
Regulation of Complement Protein Gene Expression, Harvey R. Colten and Gérard Garnier
Biology
Characterization of Complement Anaphylatoxins and Their Biological Responses, Julia A. Ember, Mark A. Jagels, and Tony E. Hugli
Complement-Mediated Phagocytosis, Melvin Berger
Cellular Responses to the Membrane Attack Complex, Carolyn Mold
Regulation by Complement of Acquired Immunity, Michael C. Carroll and Douglas T. Fearon
Endothelial Cell Responses to Complement Activation, Soheyla Saadi and Jeffrey L. Platt
The Complement System in Reproduction, Teresa J. Oglesby
Bacteria and Complement, Franz Petry and Michael Loos
Complement and Viruses, Neil R. Cooper
Complement and Disease
Complement Deficiencies and Infection, Peter Densen
Processing and Clearance of Immune Complexes by Complement and the Role of Complement in Immune Complex Diseases, Kevin A. Davies and Mark J. Walport
C1 Inhibitor Gene and Hereditary Angioedema, Alvin E. Davis III
Paroxysmal Nocturnal Hemoglobinuria and Complement, Wendell F. Rosse Complement in Central Nervous System Disorders, Moon L. Shin, Horea Rus, and Florin Niculescu
Development of Clinically Useful Agents to Control Complement-Mediated Tissue Damage, Eric Wagner and Michael M. Frank
Autoimmune Hemolytic Anemia, Alan D. Schreiber
Complement an
