ABSTRACT
This chapter is based on the separation of l-Glutathione (GSH)/glutamic acid using a simulated moving-bed adsorber system. The optimal operation of the simulated moving-bed adsorber was then found experimentally, using a system controlled by a personal computer, in which the countercurrent movement of the adsorbent was caused by a specially designed rotary valve. GSH produced by yeast fermentation is a useful tripeptide as medicine for liver complaints, and an antidote. Industrially, GSH of around 99% purity is usually required in the crystallization step. Both the purity and the yield of GSH could be increased to around 99%, and the concentration of GSH in the recovered solution and the production of GSH for the amount of adsorbent were greatly improved. It is worth noting that the concentration of GSH and the productivity of GSH on the amount of adsorbent used by the simulated moving-bed adsorber were greater by as much as 10 times and 18 times compared with the conventional operation.
