ABSTRACT
In cross-current systems the chromatographic bed moves perpendicularly to the direction of fluid motion within the bed. The chromatographic process that takes place in the continuous cross-current chromatograph is a steady-state separation occurring in the axial and circumferential directions. An analytical chromatograph can provide a highly efficient separation of even very similar molecular species and the possibility of scaling up such processes for large-scale production has attracted much attention. C. D. Scott et al. achieved pressurization operation of a rotating annular chromatograph using an air line to provide constant overpressure. L. N. Moskvin et al. reported on the application of gradient elution chromatography in a rotating annular chromatograph. J. C. Giddings recognized that some of the inherent disadvantages of batch-type large-scale systems were avoided by employing the annular approach. The rotating annular chromatograph was used to separate sucrose from the remaining components in the multicomponent feed stock beet molasses.
