ABSTRACT
Animal models are frequently used in metabolic studies to provide predictive information on the likely behavior of foreign compounds in man. Usually a model is only applicable to a particular problem, the degree of relevance being a matter of subjective evaluation. Proper assessment can only be achieved by those who have gained a thorough understanding of both the problem and the model. Emphasis must also be given to the care and maintenance of the animals, as no experiment can be justified which subjects the animals to unnecessary suffering or hardship. For those who wish to develop and use surgically prepared animal models it is therefore important that they obtain a range of skills and knowledge on general animal experimentation, physiology, anatomy, and behavior and become competent in the use of anesthetics and surgical procedures.
