ABSTRACT
The concept that bone marrow derived stem cells (BMSC) can give rise to cells of disparate lineages began to gain widespread support in 1998, as articles first surfaced describing the presence of marrow-derived myocytes and hepatocytes in bone marrow transplant recipient mice. Subsequent reports have expanded the nonhematopoietic, nonmesenchymal cell types that can differentiate from BMSC to include mature cells of the lung, heart, GI tract, kidney, skin, and the CNS (including neurons). In addition to BMSC, neuronal stem cells are also capable of differentiating into multiple nonneural cell types.
