ABSTRACT
Respiratory illnesses pose a significant public health burden globally. Our understanding of these disorders has been hampered due to overreliance on animal models and conventional cell cultures. To address this, microfluidic microengineered systems, collectively known as lung-related organs-on-chips, have been developed to recreate the lung microenvironment with unprecedented accuracy and resolution. This chapter discusses how these groundbreaking biomimetic platforms have been utilized to reconstitute pathophysiology of major respiratory conditions such as asthma, chronic obstructive pulmonary disease, lung cancer, and pulmonary infections in vitro.
