ABSTRACT
Although the radiological diagnosis of MPM can be difficult, it is worth noting that the exercise of pathological diagnosis and histological classification of MPM is not necessarily a straightforward undertaking. The evaluation of MPM is subject to notinsignificant observer variability (21-23). An additional difficulty has been the differentiation of MPM from metastatic adenocarcinoma. However, on this last note, there have been promising advances with the development of sophisticated immunohistochemical and antibody tests (24-27) including, more recently, the identification of a possible marker in the blood (serum mesothelin-related protein) for MPM (28,29).
