ABSTRACT
The main goal of diabetes management is to rebalance the carbohydrate metabolism. In order to achieve that, changes in diet and the whole lifestyle should be adopted and of, course, proper pharmacotherapy. Drugs used in diabetes target hyperglycemia. There are different pharmacological classes of antidiabetic drugs and their selection by the physician when prescribed depends on the type of diabetes, other chronic conditions of the patient, and clinical parameters like weight, blood sugar, and hemoglobin A1C values after the beginning of treatment. Insulin sensitizers are treating insulin resistance, the main pathological mechanism of type 2 diabetes. Sulfonylureas are used for non-insulin dependent diabetes mellitus treatment. These drugs express their hypoglycaemic effects by stimulating insulin secretion from the pancreatic beta-cells. Dipeptidyl-peptidase IV is a complex enzyme that exists as a cell membrane peptidase and as a second smaller soluble form present in the circulation. Software-aided molecular design and QSAR studies have a potential in designing molecules as therapeutic agents in diabetes mellitus.
