ABSTRACT
Friccohesity involves a multistage relaxation process. The relaxation stages and steps ensure regaining and optimizing of the natural state of molecules either in the cohesive cages or in the frictional cages. The cohesive cages are divided into two categories, the positively charged and the negatively charged cages. The normal cohesive cages belong to the linkages of similar molecules, like water and water. Such state belongs to the pure solvent when the solvent molecules as per their electrostatic or London dispersive forces gain a structural state with definite physicochemical properties. The forces induce coalescence, coagulation, aggregation by causing stretching, vibration, and rotational and translation thermodynamic motions with respect to the friccohesity of the liquid mixtures. The survismeter becomes a most relevant technique to determine such changes occurring in the liquid mixtures. These effects disturb the free radical mechanism and the drug binding and release process. The survismeter methodology is adopted for the study of the molecular interaction involved in formulations.
