ABSTRACT
Pulmonary drug delivery is an expanding field, with new therapeutics either approved or in development for a range of diseases. To improve the efficiency and economy of pulmonary drug design and development, researchers can utilise animal models as a means for performing comprehensive preclinical studies. A smart and developed approach to preclinical animal models can become an invaluable tool for researchers in the early stages of drug development. This chapter begins with a reflection on the lesser considered obstacles that should be addressed by researchers when evaluating possible animal models, including ethical, logistical, and financial parameters. This is followed by a wide review of the anatomical differences across species and how they can affect pulmonary drug delivery studies, before reviewing the experimental technologies that can be applied to particular animal models.
