ABSTRACT
This chapter outlines some of the deposition models that have been used with inhaled pharmaceutical aerosols and their basis. Since some control over aerosol properties and breath pattern is possible when designing an inhaled aerosol formulation, access to tools that permit parametric exploration of lung deposition is useful in order to optimize the parameters and guide preclinical development. To overcome some of the limitations mentioned above that are associated with purely empirical models, simulations that include various aspects of the inhaled aerosol dynamics have been developed. The simplest of these belong to a class of models called Lagrangian dynamical models (LDMs), meaning that the model simulates some of the dynamical behavior of the aerosol in a frame of reference that travels with the aerosol. Some of the major limitations of existing one-dimensional LDMs and Eulerian dynamical models are caused by their consideration of only one spatial dimension.
