ABSTRACT
InŠammation is a physiological response to injury, infection, or noxious stimuli, such as allergens. In health, acute inŠammation is self-limited with complete restoration of tissue homeostasis, a process de™ned as catabasis (Serhan 2007). If an
9.1 Introduction .................................................................................................. 213 9.2 Basic Biology of Proresolution Mediators .................................................... 215
9.2.1 C20:4: Lipoxins ................................................................................ 215 9.2.2 Resolvins ........................................................................................... 216
9.2.2.1 C22:6: D-Series Resolvins ................................................. 216 9.2.2.2 C22:6: Protectins ................................................................ 218 9.2.2.3 C22:6: Maresins ................................................................. 218 9.2.2.4 C20:5: E-Series Resolvins ................................................. 218
9.3 Evidence for a Role in Airway InŠammation ............................................... 219 9.4 Drug Discovery Effort around the Target for Airway Disease ................. 222
9.4.1 In Vitro Biology ................................................................................ 222 9.4.2 Preclinical Evidence .........................................................................224 9.4.3 Clinical Evidence ..............................................................................225
