ABSTRACT
This chapter describes the utility of atomic force microscopy (AFM) in studying the structural changes induced by drug binding to single-and double-stranded deoxyribonucleic acid (DNA) at the level of individual molecules. Drugs, like intercalating agents or minor-groove-binding molecules, were incubated with single-or doublestranded DNA and their effect on the DNA conformation was investigated by means of AFM imaging.
