◾ Automated Annotation Systems
In this chapter, we are focusing on three of these tools, which can handle both prokaryotic and eukaryotic genome annotations, as well as one tool that was speci¥cally designed for the annotation of microbial genomes generated using next-generation DNA sequencing methods. ™e examples described here are typical in their design and function for the class of static genome annotation systems. Various approaches to job management, data ¥ltering, and user interfaces in genome annotation are highlighted. ™ese design principles and concepts are also applicable to many other genome annotation tools that are not speci¥cally mentioned here.