ABSTRACT
A significant capability of computational modeling is the ability to integrate components into a virtual system capable of reproducing complex behavior, incorporating circuits of information flow difficult to analyze explicitly, providing better control over and monitoring of the simulated in vivo tumor environment. The computational modeling of tumor biobarriers is dependent on adequate mathematical and in silico modeling of vascular and avascular tumors. The computational modeling of biobarriers will be an essential component of eventual successful implementation of nano-based therapeutics. The complex interaction between vascular blood flow and tumor growth was examined through an improved continuum model of solid tumor invasion with a model of tumor-induced angiogenesis. Investigate the effect of therapies designed to improve doxorubicin penetration under several combinations of drug/interstitium diffusivities, cell densities, and drug efflux activities. Since drug release kinetics of nanovectors more resembles continuous infusion, this result may directly apply to nano-based therapeutics.
