ABSTRACT
Optical coherence tomography (OCT) has been developed as an imaging modality to visualize subsurface tissue morphology at a resolution (~10 μm in tissue) approaching histology [1]. Current state-of-the-art, ultrahigh resolution systems have achieved submicron spatial resolutions in both in vivo and ex vivo imaging scenarios [2-4], allowing for the detection of biological subcellular features. In vivo endoscopic OCT systems with 10-20 μm spatial resolution have been sufficient in resolving larger structures such as muscular layers of bulk tissue in the gastrointestinal wall [5], along with extension into intraluminal imaging to detect vessel wall structures as a way to stratify patient risk or monitor the placement of stents in coronary arteries [6].
