ABSTRACT
Therapeutic Applications Chih-Hsien Lee,1,a Cheng-An J. Lin,1,b Rajkumar Rajendram2
Microbubbles are tiny bubbles (diameter 1-999 µm) that consist of a gas core surrounded by a shell. Nanobubbles are even smaller (diameter 1-999 nm). Many different types of microbubbles and nanobubbles are currently available and others are in advanced stages of development. The physical properties of these bubbles infl uence the biological effects that occur when bubbles are insonated in vivo and therefore determine the advantages, disadvantages
1Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li, Taiwan, R.O.C. a E-mail: petertrue1@yahoo.com.tw bE-mail: chengan_lin@cycu.edu.tw cE-mail: whchang@cycu.edu.tw 2Departments of Anaesthesia and Intensive Care, Royal Free Hospital, Hampstead, London, England; E-mail: rajkumarrajendram@doctors.org.uk *Corresponding author List of abbreviations after the text.
