ABSTRACT
Nowadays, gold nanoparticles play a key role in the construction of
a new generation of biosensors and, in particular, electrochemical
biosensors. This chapter is devoted to electrochemical DNA biosen-
sors coupled with the use of gold nanoparticles to improve both
oligonucleotide immobilization on electrode surfaces and signal
amplification for sensitive detection of hybridization events. Recent
advances in the development of these biosensors are covered,
stressing on the improvement of the analytical performance.
Configurations used for DNA immobilization and signal transduction
and amplification strategies are treated separately.
