chapter  5
Surface-Wave Enhanced Biosensing
Pages 24

In 1983, a seminal paper by Bo Liedberg et al. introduced the first concept for the use of a particular type of surface waves, surface plasmon polaritons or surface plasmons for short, for biosensing [1]. Shortly thereafter, the first commercial implementation of surface plasmon resonance (SPR) spectroscopy for the detection of bioaffinity reactions appeared on the market [2]. Now, 30 years later, we look back to a remarkable success of this concept with numerous instruments being commercially available and a variety of modifications and extensions of the original principle being developed and described in the literature [3].