ABSTRACT
I. Introduction The unique microbiology of cystic fibrosis (CF) lung disease has been appreciated for decades. Fulminant pneumonia with Staphylococcus aureus was described in infants with CF in the 1940s along with the initial descriptions of CF (1), and S. aureus was the most common pathogen isolated (2). Descriptions of the epidemiology of Pseudomonas aeruginosa were first provided in the 1960s, including the unique mucoid phenotype (3-5). Initial reports of the “cepacia syndrome” appeared in the late 1970s and early 1980s (6,7).
