ABSTRACT

The homeostasis of glucose is one of the most involved and refined systems in a human organism [17]. By current concepts, the highly refined mechanism of regulating the homeostasis of various metabolic parameters, and in particular the homeostasis of glucose, includes two systems, namely, the hormonal and neural ones. Nevertheless, in recent years, the concept of metabolic control or the theory of regulation by metabolites [62, 63] in the regulation of glucose homeostasis is constantly gaining interest. The postulate developed in the cited references on the self-regulation of the metabolic paths makes it possible to explain in a new way the relation between the hormonal and substrate unit in the regulation of glucose metabolism, and also the mechanism of the effect of a number of hormones, in particular of insulin.