ABSTRACT
This chapter briefly reviews the pathophysiology of ischemic stroke and treatments proposed in preclinical models, and especially focus on PGD2 and the role of its DP1 receptor
10.1 Introduction ..................................................................................................................................................................... 97 10.2 Stroke Pathophysiology ................................................................................................................................................... 98 10.3 Hypoxia, Free Radical Damage, Energy Depletion, and Neuronal Depolarization ........................................................ 98 10.4 Excitotoxicity, Calcium Signaling, and Activation of Prostanoid Synthesis ................................................................... 98 10.5 Treatments Available for Stroke .................................................................................................................................... 100 10.6 AA Cascade ....................................................................................................................................................................101
