ABSTRACT
Chronic wounds represent an enormous burden and challenge for patients, society, and the health care systems.
As the treatment is diffi cult and long-term, it requires expensive medical attention. In addition, patients are at constant danger of developing infections, or, of becoming immobile due to their illness. Severe complications such as tissue necrosis and gangrene result in many cases in amputations of the effected extremities. The actual risk of amputation described is not very homogeneous in the literature; therapies fulfi lling the requirements of evidence based medicine are rare(Chantelau 2002).
