ABSTRACT
PrP/M ice ............................................................................................................. 5 1.3.2 Nociceptive Response of PrP+/+ and PrP/Mice Under Acute
Stimulation .......................................................................................................... 6 1.3.3 Nociceptive Response of PrP+/+ and PrP/Mice in Response to Nmda
Treatment ............................................................................................................. 9 1.3.4 Nociceptive Response of PrP+/+ And PrP/Mice Under Neuropathic
Pain .................................................................................................................... 10 1.4 Conclusion ......................................................................................................... 12 1.4.1 Statistical Analysis ................................................................................... 12 Keywords ................................................................................................................... 12 Authors’ C ontributions ............................................................................................... 12 Acknowledgment ....................................................................................................... 13 References .................................................................................................................. 13
1.1 INTRODUCTION
Cellular prion protein (PrPC) inhibits N-methyl-D-aspartate (NMDA) receptors. Since NMDA receptors play an important role in the transmission of pain signals in the dorsal
horn of spinal cord, we thus wanted to determine if PrPC null mice show a reduced threshold for various pain behaviors.
