ABSTRACT

Division of Microbiology & Systems Biology, TNO Innovation of Life, P.O. Box 360|3700 AJ Zeist|the Netherlands.

Email: an.li@tno.nl * Corresponding author: peter.punt@tno.nl

Industrially useful organic acids especially di-, tricarboxylic acids have a broad range of applications in our daily life. Traditionally, many of them were isolated from natural plant resources like lemons and apples. Subsequently most of them have been produced chemically from fossil resources, and more recently several of them are being produced by microorganisms using carbohydrate substrates.