Scientific Requirements for the Next-Generation Semantic Web-Based Chemogenomics and Systems Chemical Biology Molecular Information System OPS
Molecular information systems play an important role in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. Herein we outline the scientiic requirements followed by the IMI Open PHACTS consortium for the design of the OPS information system built on the integration of compound-target-pathway-disease/ phenotype data. Typical scientiic competency questions provided by the consortium members will be analyzed based on the underlying data concepts and data associations needed to answer the questions. Publicly available data sources will be listed, and the need and potential of semantic web-based technology will be presented.