ABSTRACT

There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistic

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Part 1 Key concepts in respiratory genetics

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chapter |3 pages

Fine mapping of disease genes

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chapter |16 pages

STANDARD DESIGNS FOR ASSOCIATION STUDIES

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Key learning points

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chapter 5|1 pages

Bioinformatics

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chapter |10 pages

Public databases and SNPs

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Find known SNPs in a gene

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chapter 6|1 pages

Functional genomics

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chapter |7 pages

Clinical functional genomics

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chapter |5 pages

Escherichia coli expression systems

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chapter |6 pages

Circular dichroism

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Key learning points

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chapter 5|5 pages

Bioinformatics

chapter 8|8 pages

Pharmacogenetics

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Enhancing the pharmacogenetic association

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Key learning points

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Part 2 Obstructive lung diseases

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chapter |8 pages

Hypereosinophilic syndrome

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Summary

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chapter |7 pages

Familial aggregation

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Proteases and antiproteases

chapter |16 pages

Future directions

chapter 11|9 pages

Cystic fibrosis

chapter |7 pages

DISEASE MANAGEMENT/FUTURE DEVELOPMENTS

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Part 3 Interstitial lung diseases

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Familial aggregation

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REFERENCES

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Immunology of sarcoidosis

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Kveim test

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Cytokines

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Chemokines

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Part 4 Miscellaneous pulmonary conditions

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chapter |9 pages

Treatment and prognosis in PPH

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Reduced penetrance in FPPH

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Gaucher’s disease

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REFERENCES

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chapter 15|29 pages

Genetics of lung cancer

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chapter |9 pages

Pneumococcal pneumonia

chapter |6 pages

REFERENCES

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chapter 18|1 pages

Other rare lung diseases

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chapter |18 pages

Disorders of surfactant homeostasis

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Lymphangioleiomyomatosis

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PATHOGENESIS

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Physical examination

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Hermansky–Pudlak Syndrome

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Key learning points

chapter |13 pages

Glossary

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