ABSTRACT
The goal of a genetic association analysis is to show that a disease phenotype varies in a predictable manner with a marker genotype. In some respects, testing for an association between a disease phenotype (or trait) and a genotype is no different from testing for statistical association between any two variables, whether they are genetic or not. Indeed, many of the statistical techniques used to analyze ordinary statistical association are used for genetic association as well. However, there are important differences in study design and analysis and in the interpretation of the findings. In this chapter we will describe statistical methods used for testing association between a trait and a genetic marker.
