ABSTRACT

The neonatal period is a time of rapid flux and hematological

problems that present during this period as a result of a

genetic defect, immaturity, or stress and present a major

diagnostic and therapeutic challenge to the neonatologist and

hematologist alike. The recent explosion in molecular

biological techniques has allowed the elucidation of the

molecular and cellular mechanisms that give rise to the

disorders of platelets, coagulation proteins, and red cells that

present in the newborn. Because of the space allotted it is

hoped that this chapter will give the reader a broad under-

standing and appreciation of the major hematological

disorders seen in the neonatal period, especially those

involving platelets and clotting proteins.