V-ATPases in Oral Squamous Cell Carcinoma Mario Pe´rez-Saya´ns Garcı´a and Abel Garcı´a Garcı´a

Oral squamous cell carcinoma (OSCC) is the most common malig-

nancy of the oral cavity. Accounting for between 90% and 95% of

all malignant lesions of the mouth, OSCC has become practically

synonymous with oral cancer [1, 2]. The main characteristics of

OSCC, a solid tumor, are acidity and hypoxia, both ofwhich have been

implicated in tumor metastasis [3], sensitivity to chemotherapy

agents [4, 5], and proliferation [6].