ABSTRACT
High-throughput strategies involving arrays of articial tissue constructs offer tremendous promise for clinical diagnostics and fundamental cell biomechanics research. These tissue constructs consist of cells cultured in a welldened three-dimensional environment, and are becoming increasingly useful tools as researchers begin to overcome the challenges of statistical sample-to-sample variability through these high-throughput techniques. While the cell culture techniques for high-throughput screening of these tissue constructs are well established, many challenges persist in high-throughput strategies for probing changes to biomechanics induced, for example, in response to a specic drug. However, advances are being made in applying many of the wide range of imaging techniques described in this handbook to highthroughput testing, and these hold great potential. In this chapter, we review three major imaging approaches that have begun to show potential for high-throughput biomechanical testing, including optical imaging, mechanical imaging, and ion-conductance imaging.
