Monoclonal Antibodies to Monomorphic Human Histocompatibility Antigens: Class I (HIA A, B, C), Class II (HIA-DR or lA-Like Antigen), and β2 Microglobulin

With the elucidation of an immunologically determined mechanism for allograft rejection in the mouse by Gorer et ale [1] and the discovery of the relationship between a series of closely linked genetic loci and the histocompatibility antigens responsible for that immunologic mechanism in both mice and humans [2,3], the basis for an understanding of cell-mediated immunity was established. The latter function has a direct bearing on normal immune function, autoimmune disorders, the cellular reaction to inflammatory and neoplastic disorders, and allograft rejection.