ABSTRACT

Enzymes form products from substrates with high selectivity and efciency at ambient temperatures. Enzymes feature well-dened binding pockets that bind substrates during reactions using non-covalent interactions. The behavior is analogous to a lock and key system in which the substrate (key) has a complementary size and shape to the binding site (lock). Enzymes selectively promote the formation of the transition state and intermediates of a particular reaction.