ABSTRACT
The endothelial cells (ECs) are subjected to several mechanical forces and chemical insults that might result in the loss of their integrity, evoking a quick degradation of the subjacent layers, which often causes blood extravasation and complications in blood circulation. The study of molecules and mechanisms underlying ECs and blood cell signaling has been crucial for designing new drugs, novel surgery procedures, or therapies that enhance the life-span and health of the patients, who have suffered several insults on the integrity of the ECs, hence compromising the integrity and subsequent circulation in their vessels. In this sense, certain diseases like atherosclerosis, heart attack, coronary thrombosis, deep venous thrombosis, idiopathic thrombocytopenic purpura, diabetic feet, etc. share common elements during their development.
