ABSTRACT

Marrow graft failure is a serious complication of stem-cell transplantation. Approximately 10% of patients who undergo either autologous or allogeneic bone marrow transplantation (BMT) fail to reconstitute or develop late he­ matopoietic failure. The survival rate of patients who develop graft failure is less than 20%. Mortality is generally related to infection as opposed to recur­ rent disease, which is the leading course of death in patients who undergo transplantation and have normal hematopoietic recovery.