ABSTRACT
The pharmaceutical industry is aiming to develop improved and efficient manufacturing processes to address current market challenges. Stronger competition among drug manufacturers and increasing government regulations over prescriptions have endured particular focus on production costs. Pharmaceutical substances are still commonly acknowledged as the backbone of modern medicinal therapy. This fact is driving research and development (R&D) processes toward more effective drug treatments for the wide variety of human diseases, with interesting developments in the biotechnology sector. Biopharmaceuticals have been gathering particular attention in this context due to its efficiency in the treatment of complex health diseases, including cancer, autoimmune and inflammatory disorders, organ transplant rejection, and many more are in clinical trials. However, the complexity of the production process
5.1 Introduction .................................................................................................. 107 5.2 Pharmaceutical Industry Overview .............................................................. 108 5.3 Drug Development Process Management ..................................................... 110
5.3.1 Planning and Scheduling Optimization Research ............................ 112 5.4 Biopharmaceutical Manufacturing Processes .............................................. 113
5.4.1 Bioprocesses Optimization ............................................................... 115 5.4.1.1 Planning and Scheduling Modeling ................................... 116 5.4.1.2 Modeling under Uncertainty of Operational Parameters ..... 118
5.4.2 Biopharmaceutical Optimization Models Classification .................. 119 5.4.3 Discussion and Directions for Future Work ..................................... 120
5.5 Conclusions ................................................................................................... 122 Acknowledgments .................................................................................................. 122 References .............................................................................................................. 123
deals with high manufacturing costs to assure its mass distribution. And unlike many areas of the process industry, the development of decision tools to support the production management of these biochemical processes have been fairly fostered.
