ABSTRACT
A dehydrated form of human amnion/chorion membrane allograft has been used in several reports for the improvement and cure of chronic wounds such as diabetic neuropathic foot ulcers, venous or arterial insufficiency ulcers, and pressure ulcers. Amniotic membrane (AM) is the innermost layer of the placenta. AM has a fetal origin and can be separated from the placenta by blunt dissection. The mechanisms involved in AM-induced skin re-epithelialization are largely unknown. It has been shown that AM might exert its wound healing effect by accelerating keratinocyte migration from the wound edge and inducing its differentiation, thereby contributing to the generation of intact epithelium. Wound healing is the biological process responsible for restoring tissue that has suffered a lesion, thereby compromising its morphological integrity. Normal wound healing represents a dynamic and well-ordered biological process involving soluble mediators, blood cells, the extracellular matrix, and parenchymal cells.
