ABSTRACT
ABSTRACT: Purpose: Eight patients from three families suffering from congenital superior oblique palsy (SOP) were studied, during a 7 year period in order to investigate the genetic transmission of this disease. Methods: One patient of each family came to the clinic complaining of eye deviation and head tilt. All available family members of these patients were invited and examined. According to results of the alternate prism cover” and “Bielschowsky” test and also presence of symptoms since early childhood and the absence of any history of trauma, congenital SOP was diagnosed. Results: In “Family A”, the father and his offsprings suffered from congenital SOP. Another family member also had a history of head tilt but didn’t come for examination. In “Family B”, three patients of two consecutive generations suffered from congenital SOP. Two other family members also had a history of head tilt, but didn’t come for examination. In “Family C”, the mother and her daughter suffered from congenital SOP. In the three families 4 patients were operated. Conclusion: An autosomal dominant inheritance pattern was seen.
