ABSTRACT
Until the 1930s biologists viewed adipose as a metabolically inert tissue. In the following 10-20 years evidence accumulated suggesting that adipose was metabolically active and played an important role in caloric homeostasis. Wertheimer and Shapiro presented this evidence in a classic review in 1948 (1), which largely shaped our present view of adipose as a highly active tissue with very important functions in storage, synthesis, and mobilization of lipids for provision of energy.
