ABSTRACT
Oligonucleotides diffuse poorly through biological barriers, including cell membranes. They are also rapidly degraded in vivo by nucleuses. Aiming to improve the administration of compounds, the book studies the development of nucleotide chemistry.
TABLE OF CONTENTS
part |1 pages
PART ONE General Features
part |1 pages
PART TWO Chemical Aspects
part |1 pages
PART THREE Delivery
part |1 pages
PART FOUR Biopharmaceutics
part |1 pages
PART FIVE Pharmacological Activity