ABSTRACT
Macrophage-MediatedCellDestruction453
giverisetohighnumbersofcloselyboundantibodies.Low-densityantigenssuchasRhresult inwidelyspacedantibodybinding.Notonlywilltheantibodydensityaffecttheinteraction withtheFereceptorsbutitwillalsodeterminetheextentofcomplementdeposition.Although asingleIgMmoleculecaninitiatecomplementactivation,severallgGmoleculesmustbe sufficientlycloseforcomplementactivation.
