ABSTRACT

InordertofurtherinvestigatetherelationshipofCD3SandDRexpressionbyCDScellsin HIVinfectiontomaturationalstatus,three-colorcytofluorometricstudieswererecently conductedinmylaboratory(7S).Thefindingsshowedthat(1)theHIV-relatedincreasein CD3S+CDSandDR+CDScellsreflectsanincreaseinCD3S+DR+CDScells,and(2)both naiveandmemorysubsetsofCD3S+CDScellsandDR+CDScellsareincreasedinHIV infection,butthememorysubsetincreasesaremoredramatic.Thus,itappearsthatsome CD3S+DR+CDScellsrepresentimmatureCDScells,whereasothersrepresentactivatedCDS cells.ThemechanismresponsibleforsuchabimodalincreaseinCDScellsremainsunclear.