RARs Acting as Repressors, in the Absence of Ugand

Ill. ROLE OF RETINOID RECEPTORS IN VIVO Although there is a growing body of information concerning the molecular biology of RA receptors, little is known concerning their actual physiological involvement in the various processes which are controlled by RA in vivo and the specific role that the various receptors may play in these processes. However, several studies have linked mutations in RARs with RA resistance. In a broad sense, these mutations can be classified as dominant negative.