chapter  4
Identification of Mammalian E2F Regulatory Networks Using DNA Microarray Hybridization Analyses
Pages 13

T he E2F family of transcription factors has been intensely studied since the discovery that E2F1 can interact with the retinoblastoma tumor suppressor protein. Candidate gene approaches have led to the identification of E2F targets that play a role in cell cycle regulation, DNA replication, and apoptosis. The advent of new, microarray-based ap­ proaches has gready expanded the base of knowledge about E2F and has revealed that E2F plays a role in far more cellular processes than originally envisioned. Here, we review the recent literature in which microarray technology has been used to gain insight into E2F activity.