chapter  9
Transcriptional Responses to DNA Damage: Systems-Level Delineation by Functional Genomics
Pages 16

The completion of genome sequencing in various organisms, together with the maturation of novel high-throughput biotechnologies and the development of powerful computational algorithms now allow the application of systems-level analysis to bio­ logical networks. Notable achievements of systems-biology have been in global delineation of transcriptional regulatory networks. These achievements were made possible by the rapid ad­ vance in gene expression microarray technologies and the ‘ChIP-on-chip’ technique, both of which shed light specifically on the transcriptome layer of cellular systems.