ABSTRACT
Solid-phase organic synthesis (SPOS) is a chemical cross-linking reaction which is accomplished on insoluble polymer microspheres or other materials. In SPOS, polymer microspheres are the most used medium because of their economical availability and variable operation. Generally we called these microspheres “supports” or “beads” in SPOS. The general reaction mechanism of SPOS is shown in Fig. 7.1. First, the initial reactant is conjugated to the supporting
Jing Zhang and Zhiguo Su
beads through some cleavable linkage; then, other reactants react with the components on the beads sequentially. Finally, the product is cut off by using a certain cleavage reagent.
