ABSTRACT

The common denominator of most assisted reproductive techniques (ART) is ovarian (hyper)stimulation. The scheme to expose excess female gametes to abundant sperm intended to increase fertilization may inadvertently produce multiple zygotes. In ovulation induction, the number of fertilized eggs is uncontrolled and unpredicted. By contrast, the number of zygotes transferred in ART has been always under control. Consequently, multiple pregnancies following ART are almost exclusively physicianmade, i.e., iatrogenic multiple pregnancies (IMPs).